bcl-2和p53在宫颈上皮瘤样病变与宫颈癌中的表达

The Expression of bcl-2 and p53 in Cervical Intraepithelial Neoplasia and Cervical Carcinoma

目的:探讨bcl-2、p53在宫颈上皮瘤样病变、鳞状上皮原位癌及浸润性鳞状上皮中的表达及意义。方法:用免疫组织化学方法检测宫颈上皮瘤样病变30例,原位癌25例和浸润性宫颈鳞状上皮癌30例中bcl-2、p53表达情况。结果:bcl-2在上皮瘤样病变、原位癌、浸润鳞状上皮癌中表达率分别为26.67%、44.00%和43.33%,在不典型增生与癌之间差异有显著性(P<0.05),且与组织分化程度有关;p53在上皮瘤样病变、原位癌、浸润鳞状上皮癌中表达率分别为6.67%、8.00%和26.67%,角化型和非角化型鳞状上皮癌之间表达差异有非常显著意义(P<0.01)。结论:宫颈上皮瘤样病变和鳞状上皮癌中均有bcl-2和p53表达,且p53异常表达是宫颈癌的早期事件,和宫颈癌发生有关。

Objective:To investigate expression and its relationship to clinicoPathology of bcl-2 and p53 protein in atypical squamous epithelial yperplasia(ASEH),carcinoma in situ(CIS) and infiltrated squamous epithelial carcinoma ( ISEC) of cervix.Methods:Immunohistochemical methods were used to studied the expression of bcl-2 and p53 in 30 cases of atypicalsquamous epithelial hyperplasia,25 cases of squamous in situ, 30 cases of invasive squamous epithelial cervical carcinoma.Results:The expression rates of bcl-2 in ASEH,CIS and ISEC were 26.67%,44.00% and 43.33%,respectively.The expression had significant difference between ASEH and carcinomas and depending on the differentiation degree.The expression rates of p53 in SEAH,CIS and ISEC were 6.67%,8.00% and 26.67%,respectively.it was significantly different between keratinized and nonkeratinized type of SEC.Conclusions:bcl-2 and p53 play an important role in the pathogenesis and development of cervical carcinoma and the abnormal expression of p53 is an early event of cervical carcinoma pathogenesis.