盐酸曲美他嗪对应用表阿霉素患者的cTnI、CRP、LVEF的影响

The effect of trimetazidine on cTnI, CRP, LVEF of patients received 4'epi-doxorubicin

目的探讨曲美他嗪(TMZ)对应用表阿霉素(EPI)后患者的心肌保护作用。方法应用EPI后1个月内出现心肌受损的患者42例,随机分为盐酸曲美他嗪组(治疗组)和对照组,比较2组1个月后血清肌钙蛋白I(cTnI)、G-反应蛋白(CRP)及左室射血分数(LVEF)的变化。结果治疗组和对照组患者治疗后cTnI分别为[(0.57±0.07)mg/L vs(1.12±0.08)mg/L],CRP浓度分别为[(4.9±1.2)mg/L vs (8.8±4.2)mg/L];LVEF分别为[(52±3)% vs(41±2)%],2组比较差异有统计学意义(P<0.05)。结论TMZ可明显改善应用EPI后患者的心功能,抑制cTnI和CRP浓度的升高。

Objective To investigate the protective effect of trimetazidine（TMZ） on myocardium in patients received 4＇ epi-doxorubicin （EPI）. Methods 42 patients whose myocardium were damaged because of the administration of EPI were randomly divided into two groups. 21 patients in treatment group received TMZ, the other 21 patients were in control group. After 1-month the changes of cardiac troponin Ⅰ（ cTnⅠ）, C-reactive protein （CRP） and left ventricle ejective fraction（LVEF） were observed and compared between two groups. Results After treatment the levels of cTnI in treatment group and control group were[ （0.57 ± 0.07）mg/L vs （1.12 ± 0.08）mg/L], the levels of CRP were [ （4.9 ± 1.2）mg/L vs （8.8 ± 4.2）mg/L] respectively, there were significantly decreases in these parameters between two groups（ P 〈 0.05）. At the same time, patients＇ cardiac systolic function was improved [ LVEF, （52 ± 3 ） % vs （41 ± 2） % ], there was significant differences bet ween the two groups（ P 〈 0.05）. Conclusion TMZ can improve cardiac function and reduce the serum levels of cTnI and CRP in patients received EPI.