参麦注射液对大鼠急性心肌梗死后心功能的影响

Study on the Improvement of Shenmai Injection to Ventricular Function after Acute Myocardial Infraction

目的:探讨参麦注射液对大鼠急性心肌梗死后心功能的影响。方法:结扎大鼠左冠状动脉前降支(LAD)建立AMI模型,分组:①MI 1周组;②SM 1周组;③MI 2周组;④SM 2周组(MI心梗模型组,SM参麦注射液治疗组)。另设1周、2周假手术(Sham)组。记录心率(HR)及心功能参数:平均动脉压(MAP),左室收缩压(LVSP)、左室舒张末压(LVEDP)、左室内压最大上升速率(+dp/dtmax)和下降速率(-dp/dtmax)。结果:在心梗后1周、2周时,模型组LVSP、±dp/dtmax均明显降低,而LVEDP则明显增加(P<0.01);参麦注射液治疗组LVSP、±dp/dtmax显著回升、LVEDP下降,与对应时间点MI组比较均具有显著性差异(P<0.05,0.01)。结论:参麦注射液能显著改善大鼠急性心肌梗死后的心功能。

Objective：to investigate the improvement of Shenmai Injection to ventricular function after acute myocardial infraction（AMI）. Methods： AMI model was constructed by binding LAD. Forty-eight infractional rats were grouped at random into Group MI for 1 week,Group SM for 1 week,Group MI for 2 weeks, and Group SM for 2 weeks,and meanwhile Sham Group Ⅰ for 1 week and Sham Group Ⅱ for 2 weeks were set up as well. The following data were collected： HR, MAP, LVSP, LVEDP, LVSP （＋ dp/dtmax） and （-dp/dtmax）. Results：after one and two weeks of AMI in model groups,LVSP,and ±dp/dtmax were lowered significantly while LVEDP was raised significantly（P〈0.01）;in treatment groups by Shenmai Injection, LVSP and ＋dp/dtmax were significantly rebounded while LVEDP was significantly dropped, which formed significant difference（P〈0. 05,0. 01）in comparison with that in AMI groups at corresponding time points. Conclusion： Shenmai Injection could significantly improve ventricular function of rats contracted with acute myocardial infraction.