抗鹅膏肽的固相合成

Study on Solid-Phase Synthesis of Antamananide

采用Fmoc固相合成法合成直链多肽,并用DCC-HOBT环化法合成了抗鹅膏肽(Antamananide),结果表明:所得的直链多肽收率为64%,纯度为95%;所得的环化产品中抗鹅膏肽的含量在25%以上.

Adopt Fmoc solid-phase synthesis method to synthesize the linear peptide, and use DCC-HOBT method to cyclize the antamananide the result of study shows： the resulting that the linear peptide is 64%, the purity is 95% ; the content of Antamananide is above 25% in the products.