微波辐射相转移催化合成对羟基苯甲酸杉酯的研究

Synthesis of Benzyl 4-Hydroxy Benzoate under Microwave Irradiation and in Presence of Phase Transfer Catalyst

以对羟基苯甲酸和氯化苄等为原料,以十六烷基溴化铵为相转移催化剂合成对羟基苯甲酸苄酯。通过实验考察了催化剂用量及物料配比等因素对酯化反应的影响。结果表明:微波辐射功率350W,辐射时间3min,n(对羟基苯甲酸)∶n(氯化苄)=1∶2,n(正十六烷基三甲基溴化铵)∶n(对羟基苯甲酸)=0.025,产率可达96.7%。

Benzyl 4-hydroxybenzoate is directly synthesized by 4-hydroxybenzoate and benzyl chloride under microwave Irrad- Iation and In presence of phase transfer catalyst In alcohol, experimental results show that n（to the hydroxyl benzoic acid）/n （chlorinebenzyl） = 1 .-2, n（CTMAB）/n（ 4-hydroxy benzoic acid）= 0. 025, microwave radiation power is for 350W, irradiation time is 3 min, and the yield of the ester is 96.7% respectively.