重症监护病房铜绿假单胞菌耐药性分析

Resistance of Pseudomonas aeruginosa in ICU

目的了解医院2003年1月-2006年12月重症监护病房铜绿假单胞菌的耐药情况,给临床使用抗菌药物提供参考。方法收集重症监护病房分离的铜绿假单胞菌,培养鉴定,采用纸片扩散法(K-B法)测定其对12种抗菌药物的敏感性。结果427株铜绿假单胞菌其药物敏感率依次为亚胺培南82.2%、哌拉西林/他唑巴坦74.94%、哌拉西林67.92%、阿米卡星64.87%、头孢他啶59.95%、妥布霉素等52.93%、头孢吡肟49.88%、环丙沙星49.65%、头孢曲松44.50%、庆大霉素41.92%、氨曲南38.17%和头孢噻肟35.60%。结论铜绿假单胞菌仅对亚胺培南、哌拉西林/他唑巴坦、哌拉西林、阿米卡星、头孢他啶、妥布霉素等抗菌药物保持较高敏感性;对环丙沙星及氨曲南的敏感性低;对多种抗菌药物具有高度耐药性,应根据药敏结果合理选用抗菌药物。

OBJECTIVE To understand the antibiotic resistance of Pseudemonas aeruginosa isolated from ICU and give advices to clinicians. METHODS The antibiotic susceptibility of P. aeruginosa isolated from ICU to 12 kinds of antibiotics were tested by disc diffusion method. RESULTS The antibiotic susceptibility of 472 P. aeruginosa strains to imipenem, piperacillin/sulbactam, piperacillin; amikacin, ceftazidime; tobramycin, cefepime, ciprofloxacin, ceftriaxone, gentimicin, aztreonam and cefotaxime were 82.2 %, 74. 94%, 69. 92%, 64. 87%, 59.95%, 52.93%,49.88%, 49.65%, 44.50%,41.92%, 38.17%, and 35.60%, respectively. CONCLUSIONS P. aeruginosa isolated from ICU of our hospital is suscepitable to imipenem; piperacillin/sulbactam, piperacillin, amikacin and the cephalosporins; but show lower susceptibility to other antibiotics.