小儿轮状病毒肠炎致肠管外损害65例临床研究

A Clinical Study of Extraintestinal Involvement after Rotavirus Enteritis in 65 Infants

目的:探讨小儿轮状病毒肠炎致肠管外损害的临床表现及实验室检查结果。方法:对148例腹泻病患儿采用酶联免疫吸附试验(ELISA)检测大便中的轮状病毒,阳性65例确诊为轮状病毒肠炎并设为观察组,阴性83例为对照组,对比两组的肝功、心肌酶、中枢神经系统损害状况。结果:观察组与对照组相比在年龄构成上无显著性差异(P>0.05)。肝功能酶学指标(ALT)较对照组升高,但无显著性差异。心肌酶学指标(CK-MB,LDH,AST)明显升高(P<0.05),观察组下呼吸道感染、中枢神经系统损害发生率明显高于对照组(P<0.05),年龄越小,心肌损害比例越高。结论:轮状病毒肠炎可导致肠管外多脏器损害,尤以心肌损害为多见。

Objective： To study the clinical manifestations and the laboratory results of extraintestinal organ damage after rotavirus enteritis in infants; Methods： 148 children with acute diarrhea were hospitalized from October 2004 to March 2006, whose fecal samples were obtained. Enzyme linked immunosorbent assay（ELISA） was used to detect rotavirus（RV）. According to the result of blood, the patients were divided into RV positive group （detected group, 65 children） and RV negative group （control group, 83 children）. The differences between these two groups of extralntestinal organ（such as liver, heart, the central nervous system）damage were analyzed. Results： There was no difference between detected group and control group in age. The concentrations of ALT in detected group were higher than in control group, but there was no significant difference. The concentrations of CK-MB,LDH and AST were all higher in detected group （P〈0. 05）. The incidences of lower respiratory tract infection and the central nervous system involvement in detected group were signifieantly higher than those in control group（P〈0.05）. The young ,the higher incidences of heart injury. Conclusion： This study indicated that rotavirus can cause extraintestinal organ damage besides diarrhea, and heart injury is the most common.