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天然产物Epibatidine的全合成研究进展 被引量:4

Progress on Total Synthesis of Epibatidine
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摘要 本文综述了天然产物Epibatidine的全合成研究进展,参考文献16篇。 This paper reviews the progress on the total synthesis of the alkaloid, epibatidine, with 16 references.
出处 《有机化学》 SCIE CAS CSCD 北大核心 1997年第2期97-105,共9页 Chinese Journal of Organic Chemistry
关键词 全合成 EPIBATIDINE 镇痛活性 生物碱 total synthesis, Epibatidine, analgesia
  • 相关文献

参考文献2

  • 1Huang D F,Tetrahedron Lett,1994年,34卷,4477页
  • 2Li T C,Bioorg Med Chem Lett,1993年,3卷,2759页

同被引文献47

  • 1SPANDE T F, EDWARDS H M, YEH H J, et al. Epibatidine : A Novel (Chloropyridyl) - azabicycloheptane with potent Analgesic Activity from an Ecuadoran Poison Frog[J]. J. Am. Chem. Soc.. 1992. 114. 3475.
  • 2WATI' A P, VERRiER H M, O'CONNOR D. Resolution of synthetic ( + ) - and( - ) - Epibatidine by chiral high performance liquid chromatography and identification of the natural isomer[ J]. Liq. Chromatogr. , 1994, 17: 1257.
  • 3FLETCHER S R, BAKER R, CHAMBERS M S, et al. Regioselectivity in the Palladium - Catalyzed Addition of Carbon Nucleophiles to Dihydropyran Derivatives [ J ]. J. Org. Chem. , 1994, 59 : 1771.
  • 4OLIVO H F, HEMENWAY M S. Recent Syntheses of Epibatidine[J]. Org. Prep. Proced. Int. , 2002, 34: 1.
  • 5COREY E J, LOH T R. Stereocontrolled Total Synthesis of ( + ) - and ( - ) -Epibatidine[J]. J. Org. Chem. , 1993, 58:5600 - 5602.
  • 6AOYAGI S, TANAKA R, KIBAYASHI C. Total Synthesis of ( - ) - Epibatidine Using an Asymmetric Diels - Alder Reaction with a Chiral N - Acylnitroso Dienophile[ J]. J. Org. Chem. , 1998, 63 : 8397 - 8406.
  • 7AOYAGI S, TANAKA R, KIBAYASHI C. Asymmetric Total Synthesis of ( - ) -Epibatidine[J]. Tetrahedron Lett. , 1998,39:4513-4516.
  • 8HOASHI Y, YABUTA T and TAKEMOTO Y. Asymmetric Synthesis of ( - ) - Epibatidine [ J ]. Tetrahedron Lett. , 2004, 45 :9185 -9188.
  • 9TACHIHARA T H, WATANABE, KITAHARA T. Formal Total Synthesis of both Enantiomers of Epibatidine [ J ]. Heterocycles, 2002, 57(5) : 781 -785.
  • 10DERRICK L, CLIVE J, VINCE S C. Formal Synthesis of Natural Epibatidine and of its Enantiomer[ J]. Tetrahedron Lett. ,1998, 39 : 4789 - 4792.

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