含金鸡钠碱的光活性聚合物2.含辛可宁的两亲单体及其两亲聚合物

Optically Active Polymers with Cinchona Alkaloids 2. Cinchonine-containing amphiphilic monomers and polymers

通过两亲单体２－丙烯酰胺基烷磺酸（ＡＭＣｎＳ）与辛可宁（ＣＮ）成盐后再聚合，或ＡＭＣｎＳ聚合成梳型两亲聚合物后再与ＣＮ成盐，可获得含辛可宁的两亲聚合物。ＡＭＣｎＳ－ＣＮ盐及其相应的两亲聚合物（当ｎ＝６或１６时）具有比ＣＮ好得多的溶解性，易溶于氯仿、ＴＨＦ、乙醇、ＤＭＦ和ＤＭＳＯ等极性不同的溶剂。ＡＭＣｎＳ－ＣＮ盐在乙醇／氯仿（Ｖ／Ｖ＝１／２）中比旋光度等于辛可宁的比旋光度与辛可宁在盐中重量百分数的乘积，而相应两亲聚合物的比旋光度则不能用相似公式进行计算，说明聚合物主链对辛可宁单元的旋光性有重要影响。含ＣＮ的两亲聚合物与ＰＡＭＣ１６Ｓ相似。

Cinchonine-containing amphiphilic polymers may be obtained either by salification of 2-acrylamidoalkanesulfonic acid(AMC nS) with cinchonine (CN)followed by polymerization, or by polymerizing AMC nS to form the comb-type amphiphilic polymers PAMCnS and then salifying them with CN. AMC nS-CN salts and their corresponding amphiphilic polymers (when n=6 or 16) have much better solubility than CN, and are readily dissolved in solvents with different polarities, such as chloroform ,THF, ethanol, DMF and DMSO.The spacific rotation of an AMC nS-CN salt in an ethanol/chloroform(V/V=1/2) mixed solvent is equal to the product of the specific rotation of CN and the weight fraction of CN in the salt. However, the specific rotation of the amphiphilic polymers can not be calculated by using the similar formula, indicating that the main chain plays an important role in influencing the rotation of the cinchonine units. Like PAMC 16 S, the cinchonine-containing amphiphilic polymer exhibits the typical feature of a polyelectrolyte in ethanol.