生物还原性药物与肿瘤治疗

Bioreductive Drugs in Cancer Therapy

概述国内外研究较多的几种生物还原性药物的酶作用机制、实验发展和用于肿瘤治疗的新型药物设计及其应用情况。

Bioreductive drugs require metabolic reduction to generate cytotoxic metabolites.This process is facilitated by appropriate reductases and the lower oxygen conditions present in solid tumours compared with normal tissues. This paper gives the enzymological mechanisms of these compounds, their experimental developments and the status on the design and application of novel agents and their usages in cancer therapy.