纳米级磁共振造影微粒的制备与特性研究

Preparation and Characteristics of Nanoparticle used as the Contrast Agent for Abdomen MRI

目的:制备出磁响应性强、粒径小且分布均匀的纳米磁性微粒,为磁共振造影提供一种新型材料。方法:利用微粉化处理、悬浮稳定制备出纳米磁性微粒,通过扫描电镜和原子力显微镜观察微粒的形态和大小,磁强计检测微粒的磁响应性。结果:该法制备的磁性微粒多呈球形,其粒径为纳米级。在外加场强为104Oe、外部温度为18℃的条件下微粒的磁响应强度为(26.0±1.1)emu/g,撤除磁场时剩磁为零,显示微粒具有超顺磁性。结论:用该法制备的磁性微粒,具有有效粒径小、磁响应性好的优点,可作为一种新型磁共振造影剂。

Objective： To improve the method of synthesizing magnetic particles , which have good magnetic property and small size , to be used in contrast agent for abdomen MRI. Methods： The nanoparticles were prepared by micronization and stabilization of flowable technology. The size and shape of the particles were verified by scanning elect ron microscope （SEM） , the morphology was investigated by atomic force microscope （AFM） , and the magnetic property was evaluated by magnetometer. Results： Most of the DCIONPs showed shape of sphere, as indicated that the nanoparticles were tiny and in conform size. The magnetic responsewas （26. 0 ±1. 1） emu/g in a magnetic field of 10^4Oe and the remanence was zero without it , suggesting the nanoparticles＇ superpararnagnetism. Conclusion： The nanoparticles prepared by ultrasonic coprecipitation method have the advantages of small size, good magnetic property, and can be used as the contrast agent for abdomen MRI.