脑深部肿瘤立体定向铱-192核素瘤内近距离照射的研究

CT-Guided Stereotactic Interstitial Iridium-192 Irradiationfor Treatment of Brain-deep Seated Tumors

采用立体定向技术可以准确的把放射性核素置入脑瘤进行近距离放疗。本文报告１９９１年１２月３１日以来立体定向对脑深部肿瘤１４２例进行了铱－１９２后装管置入进行间质内放疗。男１０６例，女３６例，年龄５￣７７岁，平均３５．９岁，肿瘤位置：额叶内２９例，顶叶内２５例，颞叶内５例；枕叶内６例；脑实质内多发灶１８例，丘脑基底节区２８例，三脑室后部１３例，鞍区８例；其它部位共１６例，立体定向活检证实；

CT-Guided stereitactic procedures make it easy to place radioactive material in tu-mors at exact and reproducible sites. A stereotactic program of interstitial iridium-192 radiothera-py in deep-seated brain tumors has been applied in 142 cases since December 31, 1992. There were106 males and 36 females, ranging in age from 5-77 years (median 35. 9 years). Primary and re-current tumor sites included the frontal lobe (29), parietal lobe (25), temporal lobe (15), multi-ple 18, Posterior of third ventricle (13), basal ganglion (28), occipital lobe (6), and other lesions(10). Stereotactic biopsy were astrocytoma in 80 cases, glioblastoma in 13, oligodendroglioma in5, ependyma in 2, metastasis in 12, lymphoma in 2, meningioma in 4, pinealocytoma in 13, cran-iopharyngioma in 5, chordoma in 2, colloid cyst in 1, engioneoplasm in 1 and medulloblastoma in2. 120 Patients were up up followed from 1 to 4 years, with a median of 2. 2 years. Our resultsshowed that the median survival of this group of patients was 26 months which wasw significantlyhigher than the median survival of 13 months for a group of similar patients treated without an im-plant boost.