2-芳基丙酸类消炎镇痛药物的研究──7用1,2-芳基重排法合成酮基布洛芬

STUDIES ON THE ANTIINFLAMMATORY DRUGS OF 2-ARYLPROPANOIC ACIDS──6 SYNTHESIS OF KETOPROFEN BY 1,2-ARYL REARRANGEMENT

以3-溴苯丙酮（2）为起始原料，经1，2-芳基重排、水解制得2-（3-溴苯基）丙酸（3）。再经羧基保护、格氏反应、水解、氧化即得酮基布洛芬（1），总收率43．7％。

A convenient synthetic process for ketoprofen was reported. 3-Bromopkenyl ethyl ketone (2) via 1. 2-aryl rearrangement and hydrolysis was subjected to protection of carboxylic group, Grignard reaction. hydrolysis and oxidation to give ketoprofen in ac overall yield of about 43. 7%.