摘要
目的研究西归醇提物的抗疲劳机理。方法用西归醇提液给小鼠灌胃20d,剂量为1.25,2.50,5.00g/(kg·d),阳性对照组用人参浸膏液灌胃20d,剂量为0.35g/(kg·d),测定各组小鼠游泳后的血乳酸(LD)含量、乳酸脱氢酶(LDH)活力、肝糖原含量。结果与阴性对照组比较,西归醇提物各剂量组小鼠游泳后的LD水平显著降低(P<0.01),LDH的活力提高(P<0.05);西归醇提物2.50g/(kg·d)组小鼠的肝糖原含量显著提高(P<0.01)。结论西归醇提物可能通过提高LDH活力来降低血LD水平,并通过提高糖原的储存量来发挥抗疲劳作用。
Objective To study the mechanism of anti- fatigue effect of extract of seselopsis extract on mice. Methods The seselopsis extract was given to the experimental mice with gastric perfusion in a dose of 1.25, 2.50, 5.00 g/（kg · d） for 20 d, while the ginseng extract was given to the control mice with gastric perfusion in a dose of 0.35 g/（kg· d） for 20 d. Following mouse swimming test,blood lactic acid （LD）, serum lactate dehydrogenase （LDH）, and glycogen in the liver were determined. Results The seselopsis extract could significantly increase the serum LDH activity and decrease blood lactic acid in mouse, Compared with the control group, glycogen storage in the liver was also improved, Its effects were similar to that of ginseng. Conclusion The seselopsis extract may exert its anti- fatigue effect via decreasing LD by activating LDH in the blood, and improve glycogen storage in the mouse liver.
出处
《中国药业》
CAS
2008年第3期6-7,共2页
China Pharmaceuticals
基金
大理学院科研项目
项目编号:2006DX10
