银杏叶提取物对冠心病患者冠状动脉血流的影响

Effect of Ginkgo Biloba Extract on coronary blood flow in patients with coronary artery disease

目的:研究银杏叶提取物对冠心病患者冠状动脉血流的影响。方法:90例经冠状动脉造影证实的冠心病患者随机分为银杏叶提取物注射液治疗组和对照组(各45例),两组均于用药前、后采用经胸超声心动图检测冠心病患者冠状动脉左前降支(LAD)血流的变化。结果:银杏叶提取物注射液显著增加冠心病患者LAD舒张期峰值流速、收缩期峰值流速和舒张期时间速度积分(P<0.01);而对照组LAD血流无明显变化(P>0.05)。结论:银杏叶提取物注射液可增加冠心病患者LAD血流。

AIM： To investigate the effect of Ginkgo Biloba Extract on coronary blood flow in. patients with coronary artery disease （CAD）. METHODS： Ninety CAD patients confirmed by cardioangiography were randomly assigned to Ginkgo Biloba Extract Injection group （ n = 45 ） and control groups （ n = 45 ）. Before and after intravenous administration, the distal left anterior descending coronary artery （LAD） flow was measured by transthoracic Doppler echocardiography. RESULTS： Ginkgo Biloba Extract Injection treatment demonstrated significant improvement in diastolic peak velocity, systolic peak velocity and diastolic time velocity integral （P 〈 0.01 ）. In contrast, saline had no effects on these parameters （ P 〉 0.05 ）. CONCLUSION ： CAD patients in the treatment of Ginkgo Biloa Extract lead to the increase in LAD blood flow.