一氧化氮与肝硬化高动力循环

Nitric Oxide and Hyperdynamic Circulation in Cirrhosis of Liver

对72例肝硬化患者和30例正常人血浆NO2／NO3水平和门静脉血流量、心率与平均血压进行测定，探讨NO与肝硬化高动力循环之间的关系。结果显示肝硬化代修组和失代佳组血浆NO2／NO3水平明显高于正常对照组（P＜0．05及0．001）。失代偿组血浆NO2／NO3水平与心率呈显著正相关，与平均血压呈负相关（P＜0．001），与门静脉血流量呈显著正相关（P＜0．05）。结果提示肝硬化患者体内NO水平显著增高，NO的过量产生是肝硬化患者血流动力学紊乱的重要原因。

The plasma nitrite and nitrate (NO2 NO3) anionic ratio was detected and the portal blood flow(PBF), heart rate (HR) and mean blood pressure (MBP) were measured in 72 patients with liver cirrhosis and in30 normal persons in order to study relationship between nitric oxide (NO) and hyperdynamic circulation in cirrhosis. The results showed that plasma ratio of NO2NO3 was significantly increased both in patients with componsated liver cirrhosis (CLC) and in those with decomponsated liver cirrhosis (DLC) (36. 8 + 14. 1μmol/1； 60. 1 +20. 1μmol/l vs. 29. 6+ 11. 4μmol/l,P<0. 05 ;P<0. 001,respectively): It was positively correlated with HR and inversely with MBP (r, = 0. 56,r2 = - 0. 57,P<0. 001, respectively).. The increase of plasma NO22 /NO3 was alsopositively correlated with PBF (r = 0. 68, P< 0. 05). These findings suggested that NO was overproduced in patients with liver cirrhosis, and the overproduction of No might play and important role in hemodynamic dysfunction in patients with liver cirrhosis, especially in those with DLC. And following this fact, it might offer favorabletherapeutic options for the treatment of portal hypertension and its complications.