子痫前期患者胎盘组织中细胞间黏附分子1的表达

Expression of intercellular adhesion molecule-1 in placenta tissue of pre-eclampsia patients

目的:检测子痫前期患者和正常孕妇胎盘组织中细胞间黏附分子-1(ICAM-1)的表达水平,探讨其在子痫前期发病机制中的作用。方法:采用免疫组化PV-9000法检测50例子痫前期患者(其中轻度子痫前期20例,重度子痫前期30例)和30例正常孕妇子宫胎盘绒毛合体滋养细胞ICAM-1的表达情况。结果:重度子痫前期患者胎盘绒毛合体滋养细胞ICAM-1的表达明显高于正常孕妇组和轻度子痫前期组(P<0.05),轻度子痫前期组与正常孕妇组ICAM-1的表达差异无统计学意义(P>0.05)。结论:重度子痫前期患者胎盘绒毛合体滋养细胞ICAM-1的表达增强,可能通过引起母胎界面炎症反应而参与子痫前期的发病。

Aim： To detect the expressions of intercellular adhesion molecule-1 （ ICAM-1 ） in the placenta tissue of pre-eclampsia and normal pregnant women, and to explore the role of ICAM-1 in the etiology of pre-eclampsia. Methods： The expression of ICAM-1 in placenta tissue of 50 women with pre-eclampsia including 30 women with severe preeclampsia and 20 women with mild pre-eclampsia and 30 normal pregnant women were evaluated by PV-9000 Polymer Detection System（immunohistochemistry）. Results：The expression of ICAM-1 in placenta tissue of severe pre-eclampsia patients was significantly higher than that of mild pre-eclampsia patients and normal pregnant women （ P 〈 0. 05 ） , while there was no difference in the expression of ICAM-1 between the mild pre-eclampsia patients and normal pregnant women （P 〉 0. 05 ）. Conclusion ： The expression of ICAM-1 in the placenta tissue in severe pre-eclampsia patients increased, which may relate to the inflammatory reaction in maternal/fetal interface and leads to pre-eclampsia.