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转录因子Sp1与肝纤维化发生关系的研究现状

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摘要 转录因子Sp1与肝纤维化发生的关系日益受到人们的关注,Sp1可以通过调控多种致纤维化因子或抗纤维化因子的基因转录,从而影响肝纤维化的发生和发展,Sp1还明显影响肝星状细胞的活化和增殖。本文对Sp1在肝纤维化中的作用作一综述。
作者 陈浩 周宇
机构地区 广东医学院附属医院消化内科
出处 《实用肝脏病杂志》 CAS 2008年第1期63-67,共5页 Journal of Practical Hepatology
关键词 肝纤维化 转录因子SP1 发生 基因转录 发展 肝星状细胞
分类号 R575.2 [医药卫生—消化系统]
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参考文献25

  • 1LEE JA,SUH DC,KANG JE,et al.Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors,and this interaction is modulated by MEK[J].J Biol Chem,2005,280(30):28061-28071.
  • 2薛丽香,翁默,吴军峰,张宗玉,童坦君.Sp1和Sp3介导的转录调控[J].中国生物化学与分子生物学报,2006,22(2):106-110. 被引量：10
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二级参考文献27

  • 1Yu B,Datta P K,Bagchi S.Stability of the Sp3-DNA complex is promoter-specific:Sp3 efficiently competes with Sp1 for binding to promoters containing multiple Sp-sites.Nucleic Acids Res,2003,31(18):5368 ～ 5376
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  • 5Taatjes D J,Tjian R.Structure and function of CRSp/Med2; a promoter-selective transcriptional coactivator complex.Mol Cell,2004,14(5):675 ～ 683
  • 6Jang S I,Steinert P M.Loricrin expression in cultured human keratinocytes is controlled by a complex interplay between transcription factors of the Sp1,CREB,AP1,and AP2 families.J Biol Chem,2002,277 (44):42268 ～ 42279
  • 7Sun J M,Chen H Y,Moniwa M,Eitchfield D W,Seto E,Davie J R.The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2.J Biol Chem,2002,277(39):35783 ～ 35786
  • 8Sun JM,Spencer VA,Li L,Yu Chen H,Yu J,Davie J R.Estrogen regulation of trefoil factor 1 expression by estrogen receptor alpha and Sp proteins.Exp Cell Res,2005,302(1):96 ～ 107
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  • 10Ishii K,Laemmli U K.Structural and dynamic functions establish chromatin domains.Mol Cell,2003,11(1):237 ～ 248

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实用肝脏病杂志
2008年 第1期

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