摘要
流行病学研究显示，血浆同型半胱氨酸（Hcy）浓度升高，个体发生骨质疏松和骨质疏松性骨折的危险增加，高同型半胱氨酸血症（hHcy）被认为是骨质疏松性骨折的一个独立危险因素。其潜在的机制可能涉及：（1）促进骨髓基质细胞凋亡，使成骨细胞生成不足，骨形成减少。（2）增加破骨细胞的数目和活性，使骨吸收增强。（3）干扰骨胶原纤维的交联。如果血浆Hcy浓度增加与骨质疏松和骨质疏松性骨折间存在因果关系，那么hHcy就可能成为骨质疏松治疗中的一种适应证。
Epidemiological studies have demonstrated that high plasma homocysteine （Hcy） levels can increase the risk of osteoporosis and osteoporotic fracture. Hyperhomocysteinemia is regarded as an independent risk factor for osteoporotic fracture. Its potential mechanisms may include that homocysteine promotes apoptosis in bone marrow stromal cells to reduce osteoblast formation and bone formation mediated by osteoblast, homocysteine stimulates osteoclast formation and activity to increase bone resorption as well as homocysteine disturbes the formation of cross-links in collagen, and so on. If the association between hyperhomocysteinemia and osteoporosis ,osteoporotic fracture is causal, hyperhomocysteinemia may become a kind of indication in prevention and treatment of osteoporosis.
出处
《国际内分泌代谢杂志》
2008年第1期66-69,共4页
International Journal of Endocrinology and Metabolism
