摘要
目的 分析成人Bamer综合征的临床特点。方法 回顾性分析2例本病。结果 2例均为青年女性，均有不同程度的多饮、多尿、肌无力和抽搐；实验室检查均表现为低血钾、代谢性碱中毒，血肾素活性、血管紧张素Ⅱ及醛固酮明显升高，而血压正常；补钾、补镁、安体舒通等治疗后症状缓解，血钾水平升高。结论 成人出现双下肢乏力，低血钾碱中毒，而血压正常时需考虑本病，本病行立-卧位肾素-血管紧张素-醛固酮测定可基本诊断，必要时行肾穿刺活检；治疗以补钾为主，辅助治疗包括补镁、前列腺素合成酶抑制剂、醛固酮拮抗剂等。
Objective To analyze the clinical characteristics of adult Bartter＇s syndrome. Methods Clinical data of 2 patients with adult Bartter＇s syndrome seen in Endocrinology department of the First Affiliated Hospital of Chongqing Medical University was analyzed. Results Both the patients were young women. The main symptoms of them included polydipsia,polyuria,muscle weakness and tetany. They both had normotensive,hypokalemie alkalosis, hyperreninemia, hyperangiotensin Ⅱ, and hyperaldostemne. All symptoms resolved after treatment with potassium and magnesium supplementation or combined spironolactone. Conclusions Bartter＇ s syndrome should be considered when patients have muscle weakness,hypokalemic alkalosis and normotensive. It can be clinical diagnosed by erect-decub position rennin- angiotensin Ⅱ-aldosterone test and renal needle biopsy when it is necessary. It can be ameliorated by potassium and magnesium supplementation,or combination with anti-aldostemne medications and/or pmstaglandin inhibitors.
