气道阻力、气道传导率正常值的测定及临床意义

Normal Values and Clinical Significance of Raw,Gaw

应用６２００ａｕｔｏｂｏｘＤＬ型体积描记仪对２２６例健康成年人和１４２例ＣＯＰＤ患者进行了Ｒａｗ、Ｇａｗ、ｓＲａｗ、ｓＧａｗ、Ｖｔｇ测定。经多元回归统计出正常预计回归方程式，并对慢性支气管炎、轻、中、重度肺气肿组以实测值占预计值比值作显著行比较，Ｒａｗ、Ｇａｗ、ｓＲａｗ、ｓＧａｗ在慢性支气管炎组，轻、中、重肺气肿组非常显著增加（Ｐ＜０．０１），随着肺气肿程度加重呈逐渐增高趋势，特别是中－重度肺气肿组气道阻力增加明显。Ｖｔｇ在轻、中、重度肺气肿组增加（Ｐ＜０．０５～０．０１），ｓＲａｗ、ｓＧａｗ在慢支组及肺气肿组非常显著增加（Ｐ＜０．０１），而肺气肿各组间无差异。表明单纯慢性支气管炎组的病变多限于小气道以上的支气管，而肺气肿患者大小气道均受累的变化规律。

In the study we measured by body plethysmograph the Raw,Gaw,sRaw,sGaw and Vtg for 226 nonsmoking healthy adults and 142 patients with COPD. The formuls for normal predict values was calculated out by multipe linear regression of the measured data from 134 healthy subjects.Comparison with the normal predict values,sRaw,sGaw but Raw,Gaw,Vtg declined markedly in smokers (P<0.05) and sRaw sGaw,Raw and Gaw decreased significantly in patients with chronic bronchitis,pulmonary emphysems and cor pulmonale (P<0.01).The results indicated that the exacerbation of smokers lung function was mainly involved in small airways,but patients with chronic bronchitis was involved in brochi above small ariways,and in patients with pulmonary emphysema and cor pulmonale the lungfunction of both large and small airways deteriorated.