期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

有机磷农药对星形胶质细胞的影响 被引量：1

下载PDF
导出
摘要 有机磷农药是我国生产和使用最多的农药,对神经的损伤是有机磷农药中毒患者致死的主要原因。研究表明星形胶质细胞可能是有机磷农药除乙酰胆碱酯酶之外的作用靶点。有机磷农药能够激活星形胶质细胞,反应性胶质化在有机磷农药的神经毒性中具有两面性,研究者们更倾向于认为它对有机磷农药神经毒性的保护作用。
作者 崔红梅 周志俊
机构地区 复旦大学公共卫生学院劳动卫生系
出处 《国外医学（卫生学分册）》 2008年第1期10-14,共5页 Foreign Medical Sciences(Section of Hygiene)
基金 国家自然科学基金(30571554) 国家科技支撑计划(2006BAI06B01)
关键词 星形胶质细胞 有机磷农药 神经毒性 反应性星形胶质化
分类号 R114 [医药卫生—卫生毒理学]
  • 相关文献

参考文献36

  • 1莫永炎,姜勇,陈瑗.脑星形胶质细胞生物学功能研究进展[J].生理科学进展,2002,33(1):71-73. 被引量：37
  • 2STRUZYNSKA L, SULKOWSKI G. Relationships between glutamine, glutamate, and GABA in nerve endings under Pb-toxicity conditions [J]. J Inorg Biochem, 2004, 98 (6) : 951-958.
  • 3LIU B, NEUFELD A H. Activation of epidermal growth factor receptors in astrocytes: from development to neural injury[J]. J Neurosci Res, 2007, 85(16): 3523-3529.
  • 4POPE C N. Organophosphorus pesticides: do they all have the same mechanism of toxicity? [J]. J Toxicol Environ Health B Crit Rev, 1999, 2(2) : 161-181.
  • 5ZURICH M G, HONEGGER P, SCHILTER B, et al. Use of aggregating brain cell cultures to study developmental effects of organophosphorus insecticides[J]. Neurotoxicol, 2000, 21(4): 599-605.
  • 6MONNET-TSCHUDI F, ZURICH M G, SCHILTER B, et al. Maturation-dependent effects of chlorpyrifos and parathion and their oxygen analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures[ J]. Toxicol Appl Pharmacol, 2000, 165 (3) : 175-183.
  • 7GARCIA S J, SEIDLER F J, CRUMPTON T L, et al. Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells[J]. Brain Res, 2001 , 891(1-2) : 54-68.
  • 8QIAO D, SEIDLER F J, SLOTKIN T A. Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells[J]. Environ Health Perspect, 2001, 109(9): 909-913.
  • 9杨晓运,李智,秦绿叶,于常海.星形胶质细胞和神经元之间谷氨酸-谷氨酰胺的代谢偶联[J].生理科学进展,2003,34(4):350-352. 被引量：36
  • 10黄景辉,洪桢,王殿仕.星形胶质细胞和突触传递的相互作用[J].神经解剖学杂志,2005,21(3):327-330. 被引量：15

二级参考文献71

  • 1Gallo V, Ghiani CA. Glutamate receptors in glia: new cells,new inputs and new functions. Trends Pharmacol Sci, 2000,21 : 252 -258.
  • 2Bacci A, Verdefio C, Pravettoni E, et al. The role of glial cells in synaptic function. Philos Trans R Soc Lond B Biol Sci, 1999, 354 : 403 -409.
  • 3Suchak SK, Baloyianni NV, Perkinton MS, et al. The glial glutamate transporter, EAAT2 ( Glt-1 ) accounts for high affinity glutamate uptake into adult rodent nerve endings. J Neurochem, 2003, 84 : 522 - 532.
  • 4Hertz L, Yu ACH, Kala G, et al. Neuronal-astrocytic and cytosolic-mitochondrial metabolite trafficking during brain activation, hyperammonemia and energy deprivation. Neurochem Int, 2000, 37 : 83 - 102.
  • 5Shaked I, Ben-Dror I, Vardimon L. Glutamine synthetase enhances the clearance of extracellular glutamate by the neural retina. J Neurochem, 2002, 83 : 574 - 580.
  • 6Ventura R, Harris KM. Three-dimensional relationships between hippocampal synapses and astrocytes. J Neurosci,1999, 19 : 6897 - 6990.
  • 7Miralles VJ, Martinez-Lopez I, Zaragoza R, et al. Na ^+- dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) in primary astrocyte cultures: effect of oxidative stress. Brain Res, 2001, 922 : 21 -29.
  • 8Butterworth RF. Glutamate transporters in hyperammonemia. Neurochem Int, 2002, 41 : 81 - 85.
  • 9Polymoropolos MH. Passive transfer of Sjogren' s syndrome lgG produces the pathophysiology of overactive bladder. Science 1997 ; 276 (5324) : 1973.
  • 10Ridet JL, Malhotra SK, Privat A, et al. Reactive AStrocytes: cellular and molecular cue to biolotgical function. TINS 1997:20:570-7.

共引文献93

同被引文献14

  • 1Betancourt AM,Burgess SC,Carr RL.Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain.Toxicol Sci,2006,92:500-506.
  • 2Guizzetti M,Pathak,S,Giordano G,et al.Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation.Toxicology,2005,215:182-190.
  • 3Zurich MG,Honegger P,Schilter B,et al.Involvement of glial cells in the neurotoxicity of parathion and chlorpyrifos.Toxicol Appl Pharmacol,2004,201:97-104.
  • 4Bliss,T.V.Young receptors make smart mice.Nature,1999.401:25-27.
  • 5Damodaran TV,Abou-Donia MB.Alterations in levels of mRNAs coding for glial fibrillary acidic protein (GFAP) and vimentin genes in the central nervous system of hens treated with diisopropyl phosphorofluoridate(DFP).Neurochem Res,2000,25:809-816.
  • 6Garcia SJ,Seidler F J,Qiao D,et al.Chlorpyrifos targets developing glia:effects on glial fibrillary acidic protein.Brain Res Dev Brain Res,2002,133:151-161.
  • 7Roy TS,Seidler FJ,Slotkin TA.Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain:regionally selective alterations in neurons and giia.Brain Res Dev Brain Res,2004.148:197-206.
  • 8Mense SM,Sengupta A,Lan C,et al.The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes.Toxicol Sci,2006.93:125-135.
  • 9Lehmann C,Bette S,Engele J.High extracellular glutamate modulates expression of glutamate transporters and glutamine synthetase in cultured astrocytes.Brain Res,2009,1297:1-8.
  • 10Mishra MK,Kumawat KL,Basu A.Japanese encephalitis virus differentially modulates the induction of multiple pro-inflammatory mediators in human astrocytoma and astroglioma cell-lines.Cell Biol Int,2008.32:1506-1513.

引证文献1

国外医学（卫生学分册）
2008年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部