HIV-1感染患者中性粒细胞吞噬及细胞内杀菌功能的探讨

STUDY OF PHAGOCYTOSIS AND INTRACELLULAR BACTERIOCIDE FUNCTION OF NEUTROPHILS IN PATIENTS WITH HIV-1 INFECTION

[目的]探讨HIV/AIDS患者不同期中性粒细胞吞噬及细胞内杀菌功能的变化。[方法]采用普通酵母菌对13例患者及50例正常人进行中性粒细胞吞噬和细胞内杀菌功能试验,并与50名正常人比较。[结果]HIV-1感染患者中性粒细胞吞噬及细胞内杀菌功能明显低于正常人(P﹤0.01),艾滋病期和艾滋病前期的患者中粒细胞数明显低于正常人(P﹤0.01)。[结论]检测HIV-1感染患者中性粒细胞吞噬及细胞内杀菌功能和白细胞数变化对探讨AIDS患者易发生重复感染原因和疾病的治疗及预后有非常重要的价值。

[Objective] To investigate phagocytosis and intraeellular sterilization funetion of neutrophils in patients with HIV-1 infeetion. [Methods] Yeast cells were used to examine phagoeytosis and intracellular baeterioeide function of neutrophils in 13 patients with HIV-1 infeetion and 50 subjects as eontrolsl [ Results] The phagoeytosis and intraeellular bacterioeide funetion of neutrophils in patients with HIV-1 infeetion were Considerably lowered than those in eontrols （P〈0.01）. [ Conclusion] Deteetion of phagoeytosis and intracellular sterilization funetion of neutrophils in patients with HIV-1 infection and the ehanged number of white blood cells may be Valuable to explore the reasons of happening superinfeetion faeilely, therapy and prognosis of AIDS patients.