昆明地区小儿急性下呼吸道合胞病毒感染的临床研究

Investigation on the respiratory syncytial virus of acute lower respiratory tract infection in Kunming children's hospital

目的了解昆明地区呼吸道合胞病毒（RSV）在小儿急性下呼吸道感染中的发生率和临床特征。方法对昆明市儿童医院2006年4月至2007年4月临床诊断为急性下呼吸道感染的住院患儿1112例行痰间接免役荧光法检测呼吸道舍胞病毒抗原。结果1112例标本中，阳性276例，阳性率24．82％，其中男190例（17．09％），女86例（7．73％），男女发病比例为2，21：1。全年均可检出RSV，发生率最高的是10—12月份（30．15％），最低的是4—6月份（10．93％）。RSV感染多见于3岁以下，尤以6个月以下患儿感染率最高（36，22％）。结论呼吸道合胞病毒是引起昆明地区小儿急性下呼吸道感染的主要病原，特别是婴幼儿感染率最高。

Objective To study the infections state of respiratory syncytial virus（ RSV ） in children suffered from acute lower respiratory tract infection from April 2006 to April 2007 in Kunming area. Methods Children suffering from acute lower respiratory tract infection（ALRl ） who were admitted to the Kunming Children＇s Hospital from April 2006 to April 2007 were chosen. Their nasopharyngeal secretions（ NPS） were obtained for identification of RSV antigen by indirect immunofluorescence assay. Results Among the all 1112 samples,276 （ 24. 82% ） positive results were determined. The ratio of male to female was 2. 21： 1. RSV all can be detected in a year,the peak seasons of RSV infection were from October to December. Most of RSV infection cases wene less than 3 years old. Conclusion RSV is the most common viral pathogen in children hospitalized with acute respiraoty infection in Kunming area