摘要
目的观察薯蓣皂苷元(MPD)对大鼠体内外血栓形成及血液黏度的影响。方法采用Chandler法形成大鼠体外血栓,测量其长度、湿重、干重;采用体内血栓形成仪,观察大鼠体内血栓形成时间;并测定大鼠高切、中切、低切下全血黏度及血浆黏度。结果与空白对照组相比,MPD中剂量组可延缓血栓形成时间,高、低剂量组也有一定的作用趋势。MPD高剂量组可降低大鼠体外血栓长度、湿重和干重。MPD高、中、低剂量组均可降低高、中、低切全血黏度和血浆黏度。结论MPD能抑制大鼠体外血栓形成,降低血栓干、湿重;延长大鼠体内血栓形成时间,降低全血黏度和血浆黏度。
Objective To investigate the effects of methyl protodioscin （MPD） on in - vitro and in - vivo thrombosis and blood viscosity in rats. Methods The vitro thrombus was induced by Chandler method, and the length, wet and dry weight of the thrombus were measured. Thrombosis instrument was to observe the in - vivo occlusion time （OT）. At the same time, determined the high - , middle -, low - shear blood viscosity as well as the plasma viscosity in rats was determined . Results Compared to normal group, middle- dose MPD group can delay the OT, and the high- dose group can decrease the length, wet and dry weight of in - vitro thrombus. The blood viscosity is reduced in all groups. Conclusion MPD can inhibit the in - vitro thrombosis, decrease the dry and wet weight of thrombus and delay the OT. Moreover, MPD has the effects of lowering the whole blood viscosity and plasma viscosity.
出处
《中药新药与临床药理》
CAS
CSCD
2008年第1期3-5,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金面上项目(C03050205)
关键词
著蓣皂苷元
体外血栓
体内血栓
全血黏度
血浆黏度
Methyl protodioscin
In - vitro thrombus
In - vivo thrombus
Whole blood viscosity
Plasma viscosity
