石菖蒲挥发油及β-细辛醚的抗血栓作用

Study on Anti-thrombosis Effect of Volatile Oil of Acorus Tatarinowii Schott and β-asarone

目的研究石菖蒲挥发油及β-细辛醚的抗血栓作用。方法通过血栓形成试验、高黏血症试验、凝血试验和体外溶纤试验,考察石菖蒲挥发油和β-细辛醚对血栓重量、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血液流变学、小鼠凝血时间、血浆纤维蛋白凝块重量等指标的影响。结果石菖蒲挥发油、β-细辛醚能减轻大鼠静脉血栓重量,延长大鼠血浆PT和APTT;改善高黏血症大鼠的血液流变性,尤其对全血低切黏度和血浆黏度的作用明显;明显延长小鼠凝血时间;减轻血浆纤维蛋白凝块的重量。结论石菖蒲挥发油、β-细辛醚有抑制血栓形成、抗黏、抗凝、溶解血浆纤维蛋白的作用,其作用机制可能与其能延长PT、APTT,改善血液黏滞性等有关。

Objective To Study on anti -thrombosis effect of volatile oil of Acorus Tatarinowii Schott （AST） and β-asarone. Methods Thrombosis test, blood hyperviscocity test, blood clottingtest, and in vitro fibrinolytic test were carried out to investigate the effects of volatile oil of AST and β - asarone on the following indexes： weight of thrombus, prothrombin time （PT）, activated part prothrombin time （APTT）, hemorheology, clotting time, the weight of plasma fibrin clot. Results Volatile oil of AST and β- asarone can lower the weight of venout thrombosis in rats, and prolong PT and APTT of blood plasma in rats. They can improve hemorheology in the hyperviscocity rats, especially reduce viscosity of whole blood and blood plasma obviously. They can prolong the clotting time in mice obviously; and decrease the weight of plasma fibrin clot. Conclusion Volatile oil of SCP and β - asarone has anti - thrombosis anticoagulationand fibrinolyitc effect, and its mechanism may be related to the prolongation of PT and APTT, improving blood viscosity.