不稳定心绞痛患者的溶栓治疗

THROMBOLYSIS THERAPY IN PATIENTS WITH UNSTABLE ANGINA PECTUS

将64例不稳定心绞痛（UAP）患者随机分成2组，一组用常规抗心绞痛药物治疗（对照组），一组加用尿激酶做溶栓治疗（溶栓组）。两组疗效比较显示：溶栓组治疗总有效率明显高于对照组（P〈0．05）。其减少心绞痛发作次数，减低心绞痛分级，改善ECG方面均优于对照组（P＜0．05）。而且血浆脂质过氧化物（LPO）明显减低，红细胞超氧化物歧化酶（SOD）活性明显升高（P〈0．05）。提示UAP患者应行尿激酶溶血栓治疗。但两组演变为急性心肌梗塞的百分率及死亡率无明显区别。

Sixty-four hospitalized patients with unstable angina pectus were divided into two groups randomly, one group receiving thrombolysis thera-py, were given urinokinase (UK) (thrombolysis therapy group); another group were given conven-tional anti-angina therapy (control group). The re-sults showed: The total effective rate of thromboly-sis therapy group were markedly higher than that of control group(P<0. 05) ; The frequency of angina attack and the class degree of angina decreased, and the ECG improved were siginificantly better in thrombolysis therapy group than in control group(P <0. 05). In hospitalized patients, there was nosignificant difference in the percentage of developing into acute myocardium infarction and in the mortali-ty. The plasma concentration of LPO was markedly decreased, and the activity of SOD in red cells was significantly increased, compared with control group (P<0. 05). It is suggested that patients with un-stable angina pectus should be given thrombolysis therapy with UK.