低蛋白质饮食对2型糖尿病早期肾病的影响

Affection of Low Protein Diet on the Patients with Early Diabetic Nephropathy Type Ⅱ

目的探讨低蛋白饮食对2型糖尿病肾病肾功能的影响。方法53例2型糖尿病患者,随机分为实验组(低蛋白治疗组)和对照组,观察低蛋白饮食对肾功能的影响,观察期6个月。结果两组患者血肾功能指标治疗前后无显著变化;尿蛋白排除和血清蛋白量有显著变化,治疗后实验组尿白蛋白排泄率明显下降,对照组尿蛋白排泄率有上升,实验组血清白蛋白治疗前后无明显变化,对照组血清白蛋白在治疗后有所下降。结论低蛋白膳食可以显著减少2型糖尿病早期肾病病人尿白蛋白的排泄,使血白蛋白增多,从而改善营养状况,保护肾功能。

Objective To discuss the affection of low protein diet on the renal function of the patients with early diabetic nephropathy type Ⅱ. Methods 53 cases were randomly divided into 2 groups ： experiment group and control group, the affection of low protein diet on the changes of blood urea nitrogen, creatinine, and serum protein level and urine protein level was observed, follow - UP lasted for 6 months. Results The blood renal function index of the patients in both groups had no obvious changes after treatment while the level of urine protein excretion and the level of serum protein increased gready; after treatment,the excretion of urine protein in experiment group decreased significantly while that in control group increased; no obvious changes of serum protein in experiment group were found after treatment, serum protein in control group decreased after treatment. Conclusion Low protein diet can significantly decrease the urine albumin excretion of the patients with early diabetic nephropathy type Ⅱ and increase the level of blood albumin, and thus improve the nutritional status and protect the renal function.