洛索洛芬钠混合性缓释片的制备

Preparation of the Mixed Matrix Tablets of Loxoprofen Sodium

目的:制备洛索洛芬钠混合性缓释片并考察其体外释放度。方法:采用混合骨架材料制备洛索洛芬钠混合性缓释片。以硬脂酸为骨架材料,并以药物在222nm的波长处的吸收度为指标考察不同比例的硬脂酸、乙基纤维素、羟丙基甲基纤维素及乳糖对洛索洛芬钠释放速率和影响因素进行考察,确定最优处方。结果:在一定范围内,随着硬脂酸量的减少,乳糖和HPMC含量增加,片剂的累积释放量增加。制备的缓释片可以持续释放药物12小时。结论:制备的洛索洛芬钠混合性缓释片缓释效果良好。

Objective： To prepare the mixed matrix tablets of Loxoprofen sodium and to evaluate their dissolution in vitro. Methods： Mixed matrix materials were used to prepare the tablets. The stearic acid was used to prepare sustained-release tablets by the wet granule compression technique. Ethylcellulose （EC） and hydroxypropyl methylcellulose （HPMC） and lactose were used to adjust the release rate. The content of the major drug was determined by UV spectrophotometry at 222nm, The release mechanism and the influence factors were studied by determining release rates. Results： The cumulative release rates of tablets increased with the decreased proportion of stearic acid and the increased proportion of lactose and HPMC. The tablets could be released continually for 12h. Conclusion： The mixed matrix tablets of Loxoprofen sodium were prepared successfully with perfect performance.