Survivin的研究现状与RNA干扰在基因治疗中的进展

Current Situation of Research on Survivin and RNA Interference in Gene Therapy

Survivin是新近发现的凋亡抑制蛋白,在正常组织中不表达而在恶性肿瘤中高表达,与肿瘤的预后、复发、转移关系密切,具有调控细胞周期,凋亡和增殖的作用;还与对化疗的耐药性和放疗的敏感性有关;此外,与肿瘤新生血管的形成关系也十分密切。针对Survivin这些特性,应用新的基因治疗技术—RNA干扰技术降低Survivin的表达可对肿瘤组织的凋亡和增殖产生影响,由于RNA干扰技术具有的高效性,特异性,长效性,使它成为肿瘤基因治疗的重要方法,应用RNA干扰技术针对Survivin靶位降低Survivin的表达有望成为今后肿瘤基因治疗的方向。

Survivin is a newly discovered inhibitor ofapoptosis protein. It doesn＇t express in normal tissues but expresses highly in malignant tumors, with regulation of cell cycles, apoptosis and proliferation, which is closely related to the prognosis, recurrence and metastasis of tumor, as well as tumor angiogenic blood vessels and drug resistance to chemotherapy and sensitivity to radiotherapy. According to the properties of Survivin, using new gene therapy technology, RNA interference technique, to reduce Survivin expression could influence the apoptosis and proliferation of tumor tissues. Because of its efficiency, long-lasting and specificity, RNA interference technology has become an important method of gene therapy in tumors; besides, with a hopeful prospect.