摘要
采用酶联免疫吸附测定法(ELISA)对85例反复自然流产(RSA)妇女及107例无流产史早孕妇女的血清进行HCMVIgM、HCMVIgG检测,应用PCR技术检测部分绒毛组织DNA,直接法制备绒毛细胞染色体。结果显示:RSA组HCMVIgM阳性率(58.82%),明显高于对照组(15.89%)(P<0.01)。说明孕妇原发性HCMV感染与RSA有相关性;HCMVIgM阳性与流产次数有密切关系;HCMV可以通过胎盘屏障感染胎儿。
Objective:To study 85 women with repeated spontaneous abortion(RSA) and 107 normal early pregnant women.Design:Using ELISA method to detect serum HCMV-IgM,HCMV-IgG and using PCR technique to examine chorionic tissue DNA by direct method to prepare chromosome in chorionic cell.Results:HCMV-IgM positive rate in RSA group (58.82%) is significantly higher than that in control group(15.89%)(P<0.01).Conclusion:RSA is correlated with primary infectin of HCMV in pregnant women.There is close correlation between the HCMV-IgM positive and the number of abortion.IgG in HCMV-IgM positive women can pass through placental-barrier to infect fetus and cause abortion. \ \
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
1997年第4期225-226,共2页
Chinese Journal of Practical Gynecology and Obstetrics
基金
国家八五攻关项目资助