摘要
目的观察清心冲剂Ⅰ号对于利培酮、奥氮平治疗精神分裂症有无增效作用。方法将清心冲剂I号合并利培酮、奥氮平治疗者作为实验1组,不合并清心冲剂Ⅰ号的作为对照1组;清心冲剂I号加氯丙嗪、氟哌啶醇、奋乃静治疗者为实验2组,不合并清心冲剂I号的作为对照2组,观察疗程8周。在治疗前及治疗后2、4、8周采用PANSS量表评价疗效。结果治疗前及治疗后实验组与对照组总体疗效比较差异无显著性(P>0.05);实验组与对照组治疗8周末PANSS和各症状评分较治疗前差异均有显著性(P<0.01),8周后实验组与对照组阳性症状分比较差异有显著性(P<0.05)。结论清心冲剂Ⅰ号对于抗精神病药物治疗精神分裂症有增效作用,尤其可以改善精神分裂症患者的阳性症状,因此在精神分裂症的治疗中有一定的临床价值。
Objective To evaluate the add-on therapeutic effect of the self-dispense herb formula-Qing Xin Chong Ji-Ⅰ combined with risperidone and olanzapine in the treatment of schizophrenia. Methods All the subjects were diagnosed as schizophrenia according to the CCMD-3 diagnosis standard and were randomized into 4 groups： the treatment group 1 （Qing Xin Chong Ji- Ⅰ combined with risperidone or olanzapine） and the control group 1 without Qing Xin Chong Ji-Ⅰ; the treatment group 2 （Qing Xin Chong ji-Ⅰ combined with chlorpromazine, haloperidol or perphenazine） and the control group 2 without Qing Xin Chong Ji -Ⅰ. The treatment lasted for 8 weeks. The Positive and Negative Syndrome Scale （PANSS） were used to evaluate therapeutic effects. Results There were no significantly difference of the total efficacy between the treatment groups and the control groups after 8 weeks of treatment （P〉 0.05）. The total scores, the scores of positive syndrome, negative syndrome and general syndrome of PANSS in the treatment group and the control groups were significantly different before and after 8 weeks（P〈0. 01）, Conclusion Qing Xin Chong Ji-Ⅰ has add-on effect for risperidone and olanzapine in the treatment of schizophrenia, especially effective for the positive symptoms of schizophrenia. It can has clinical value in the treatment of schizophrenia.
出处
《中国健康心理学杂志》
2008年第1期58-60,共3页
China Journal of Health Psychology
基金
山西省教育厅高校科研开发项目(5799814-98048)
