通冠胶囊对冠心病介入术后气虚血瘀证患者的影响

Effect of Tongguan Capsule on Post-intervention Patients of Coronary Heart Disease with Qi-deficiency and Blood Stasis Syndrome

目的观察益气活血中药通冠胶囊对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)后气虚血瘀证患者的影响。方法将100例成功施行PCI患者分为两组,每组50例。对照组手术前、中、后选用抗栓、抗凝等西药常规治疗。治疗组在对照组治疗基础上加用通冠胶囊,两组疗程均为1个月。于术前1天、术后3天和术后30天3个时间点观察以下项目:心绞痛疗效、主要中医证候、气虚证评分和血瘀证评分。结果治疗后治疗组心绞痛疗效96.0%(48/50例),对照组为92.0%(46/50例),组间差异无统计学意义(P>0.05)。PCI术后3天两组气虚证积分较术前有增加趋势,术后30天对照组较术前明显升高;术后3、30天两组血瘀证积分较术前明显降低(P<0.05)。治疗组术后30天气虚证积分和血瘀证积分较对照组均明显降低(P<0.05)。结论益气活血中药通冠胶囊能显著改善PCI术后患者气虚血瘀证表现。

Objective To observe the effect of Tongguan Capsule （TGC） , a Chinese herbal preparation for supplementing qi and activating blood circulation, in patients after percutaneous coronary intervention （PCI） with qi-deficiency and blood stasis syndrome. Methods One hundred patients after successful PCI operation were assigned to two groups, 50 in each group. Western routine therapy with anti-thrombosis and anti-coagulant agents were applied in all patients before, during and after operation, while to the patients in the treated group, TGC was given additionally. The therapeutic course for both groups was one month. The efficacy was evaluated by observing the effect on angina pectoris, main TCM syndromes and scores of qi-deficiency syndrome and blood stasis syndrome at 3 time points （ the day before, 3 days and 30 days after operation）. Results The total effective rate in relieving angina pectoris was 96.0% （48/50） in the treated group and 92. 0% （46/50） in the control group, showing insignificant difference between them （ P 〉 0. 05 ）. The score of qi-deficiency in both groups raised 3 days after PCI as compared with that before PCI, but showed no statistical significance （ P 〉 0. 05 ） ; 30 days after PCI, it increased in the control group, as compared with that before PCI （ P 〈 0. 05 ）. The score of blood stasis syndrome significantly lowered at the 3rd and the 30th day after PCI in both groups as compared with before PCI, showing statistical significance （P 〈 0. 05 ） ; while in comparing the value at the 3rd day with that at the 30th day, the difference showed significance in the treated group but not in the control group （P 〈0. 05 ） ; and comparison between the two groups at the 30th day showed it was much lower in the treated group （ P 〈 0. 05 ）. Conclusion TGC could significantly improve the clinical symptoms of qi-deficiency and blood stasis syndrome in patients after PCI.