银杏叶提取物对多柔比星所致乳腺癌患者心脏毒性的干预作用

Effect of Extract of Ginkgo Biloba on Doxorubicin-associated Cardiotoxicity in Patients with Breast Cancer

目的观察银杏叶提取物对多柔比星所致乳腺癌患者相关性心脏毒性损伤的干预作用。方法将60例Ⅳ期乳腺癌患者随机分为治疗组(银杏叶提取物加化疗)和对照组(单纯化疗),两组均予以PA方案化疗4个周期,比较两组化疗前后心电图、心肌酶谱及超声心动图的变化情况。结果化疗后治疗组心电图异常发生率为6.7%,明显低于对照组的30.0%,两组间比较,心肌酶谱差异有统计学意义(P<0.05),左心室舒张末期内径(LVDd)、左心室收缩末期内径(LVDs),舒张早期与晚期充盈速度比值(E/A)、短轴缩短率(FS)等各项指标的改变差异均有统计学意义(P<0.05),射血分数(EF)差异无统计学意义(P>0.05)。结论银杏叶提取物是预防和减轻多柔比星引起的急性心脏毒性的较为理想的药物,对慢性心脏毒性发生的减轻也有裨益。

Objective To study the effect of extract of Ginkgo Biloba （ Egb761 ） on doxorubicin-associated cardiotoxicity in patients with breast cancer （BC）. Methods Sixty BC patients in stage Ⅳ were randomly assigned to two groups, the control group was treated with chemotherapy, using 4 cycles of PA protocol alone and the treated group with the same chemotherapy and Egb761. Changes in electrocardiogram （ECG）, myocardial enzyme spectrum （MES） and uhrasono-cardiogram （USCG） before and after treatment were observed. Results After treatment, the incidence of abnormal ECG was lower in the treated group than in the control group （6. 7% vs 30. 0% ） ; significant differences were found between the two groups in the parameters of MES （P 〈 0. 05 ） ; USCG showed significant difference between the two groups in left ventricular diastolic diameter （LVDd）, left ventricular systolic diameter （LVDs）, ratio of early and late diastolic transmitral peak flow velocity （E/A） and fractional shortening （FS）, while there was no significant difference in ejection fraction （EF）. Conclusion Egb761 is an ideal drug for preventing and reducing the acute doxorbincin-induced cardiotoxicity ; it could also be helpful for alleviating the chronic cardiotoxicity.