益肾调经方防治雷公藤多甙致女性慢性肾小球疾病患者性腺衰退的临床观察

Effect of Yishen Tiaojing Recipe on Hypogonadism Induced by Tripterygium Glycosides in Women Patients with Nephropathy

目的观察益肾调经方对雷公藤多甙所致的女性慢性肾小球疾病患者性腺衰退的影响。方法将58例慢性肾小球疾病女性患者分为对照组24例,治疗组34例。对照组予雷公藤多甙片20 mg,每日3次,治疗组在对照组治疗基础上予益肾调经方,每日1剂;疗程均为3个月。治疗前后测定血清雌二醇(E2)、卵泡刺激素(FSH)、黄体生成激素(LH)及尿蛋白定量、尿红细胞计数。结果治疗前后比较,对照组E2下降,FSH、LH增高(P<0.05),治疗组E2升高,FSH、LH无明显变化,两组患者治疗后尿蛋白均有减少(P<0.05);治疗后两组间上述指标比较均有统计学意义(P<0.05)。治疗组降低尿蛋白的作用优于对照组。结论益肾调经方能防治雷公藤多甙对女性肾病患者性腺的损害,并有利于原发的慢性肾小球疾病的治疗。

Objective To explore the effect of Yishen Tiaojing Recipe （YSTJR） on sex gland and kidney in nephropathy patients with hypogonadism induced by Tripterygium glycosides （TG）. Methods Fifty-eight women patients with chronic glomerular disease were assigned to two groups, the 34 patients in the treated group were given TP 20 mg three times a day plus YSTJR, one dose daily, while the 24 in the control group were given TP 20 mg three times a day alone. The course of treatment lasted for 3 months. Serum levels of estradiol （ E2 ）, follicle-stimulating hormone （FSH）, and luteotrophic hormone （LH）, as well as urinary protein and red blood cell （RBC） count in urine were determined before and after treatment. Results Level of E2 decreased, FSH and LH increased in the control group after treatment （P 〈 0. 05）, while those indexes unchanged in the treated group. Quantity of urinary protein decreased in both two groups after treatment （ P 〈 0. 05）, but the decrement was more significant in the treated group than in the control group （P 〈 0. 05）. Differences of all the above-mentioned indexes between the two groups after treatment were significant （ all P 〈 0. 05）. Conclusion YSTJR could prevent the injury of TP on sex gland in women patients with nephropathy, and is benificial for the treatment of primary chronic renal glomerular diseases.