铝佐剂作用机制及其在人用H5N1灭活疫苗中的辅佐作用

Mechanism of Aluminum-containing Adjuvant and Its Effect on Inactivated Influenza A(H5N1)Vaccine in Medicine-a mini review

氢氧化铝佐剂已经使用了80余年,其免疫增强作用已经被人们证实,但是其详细的机理以及在使用中存在的问题尚未彻底阐明。HPAIV H5N1在世界范围内的发生引起人们的广泛关注与焦虑。有效的控制措施就是进行预防接种,但是目前使用的人用HPAIV H5N1灭活疫苗尚在研究当中,也存在一些问题。研究证实氢氧化铝佐剂的加入使该疫苗在达到相同抗体滴度的情况下可以减少抗原的用量。综述了HPAIV H5N1在氢氧化铝辅佐下的一些新认识,并对辅佐新型疫苗的开发应用前景进行了展望。

Aluminum-containing adjuvants have been used over 80 years and play a very important role in many vaccines. However, the mechanism of aluminum-containing adjuvants as well as the problems existing in their application remain uncertain. HPAIV H5N1 arouses people＇s attention and anxiety worldwide. Vaccination is an effective control measure. The use of aluminum hydroxide adjuvant will decrease the dosage of antigen whereas the vaccine reaches the same antibody titer. This paper summarizes some recent developments in HPATV H5N1 with aluminium-hydroxide adjuvant, and assesses the prospect of this new adjuvant vaccine.