女性生殖道21种亚型人乳头状瘤病毒感染与性行为、孕产史、文化程度等因素相关性分析

Relationship between 21 genotypes HPV infection of female lower genital tract and sexual behavior,reproductive history and education background

目的研究女性生殖道乳头状瘤病毒(HPV)感染和性行为、孕产史、文化程度等因素的相关性,探寻主要相关因素。方法以2005年1月～2006年8月绍兴市区门诊至少有1年以上性生活史的女性1119例为研究对象。对其阴道宫颈分泌物标本,进行21种(6、11、16、18、31、33、35、39、42、43、44、45、51、52、53、56、58、59、66、68、CP8304)HPV基因型的分型检测。同时调查其文化程度、初次性生活年龄、性生活年限、性伴侣数、避孕套/药使用情况、妊娠次数、流产次数、分娩次数等因素。用SPSS10.0软件进行卡方检验和单因素及多因素ligostic回归分析。结果初次性生活年龄过早,多个性伴侣是女性生殖道HPV感染的危险因素。分娩史,文化程度可能与HPV感染有关。性生活年限、避孕套及避孕药使用情况等因素和HPV感染无明显关系。结论初次性生活年龄,性伴侣数是HPV感染的独立相关因素。

Objective To investigate the relationship between 21 genotypes HPV infection of female lower genital tract and the potential related risk factors and to find out the main risk factors. Methods Samples of cervical and vaginal excretion from 1 119 outpatient women, who have intercourse history for at lest one year, were collected in Shaoxing from Jan. 2005 to Aug. 2006. Twenty-one genotypes of HPV （6, 11, 16, 18, 31, 33, 35, 39, 42, 43, 44, 45, 51, 52, 53, 56, 58, 59, 66, 68, CP8304） were detected in the samples. The age of first intercourse, number of sexual partners, duration of intercourse history, using of condom or pills, times of pregnancy, delivery and abortion, educational background were inquired, x^2 test and multiple factor non- conditional logistic regression analysis were used for data analysis by SPSS 10.0. Results Early age of first intercourse, multiple sexual partner were the risk factors. The times of delivery, the educational background might be the risk factors. The duration of intercourse history, using of condom or pills showed no correlation with HPV infection. Conclusions The age of first intercourse and the number of sexual partners are independent related factors of HPV infection.