胎传梅毒的实验室诊断与治疗

Laboratory diagnosis and treatment of congenital syphilis

胎传梅毒是由于孕妇感染梅毒后、梅毒螺旋体经胎盘感染胎儿而引起的一种疾病。胎传梅毒危害严重，可造成胎儿的流产、早产甚至死产等多种并发症。胎传梅毒血清学抗体检查仍然是实验室诊断的重要手段。早期诊断、及时治疗是胎传梅毒控制策略之一。虽然胎传梅毒的实验室诊断方法不断推陈出新，但判读结果时也须参考孕妇的过去史、检查、治疗等资料；同时，胎传梅毒宜根据具体情况制订不同的治疗和随访策略。

Congenital syphilis is a transplacental infection by Treponema pallidum. It is a serious disease which can result in various sequelae, including miscarriage, premature delivery, stillbirth, etc. Serological examination of antibodies is still an important approach to the laboratory diagnosis of congenital syphilis. Early diagnosis and prompt treatment is a control strategy for congenital syphilis. Although the diagnostic tests of congenital syphilis have developed continuingly, it should be combined with the mothers past history, examination results and treatment, etc, to make a reasonable decision on laboratory results. Also, it is important to make individual therapy and follow up according to the status of different cases. This paper reviews the advances in the research of congenital syphilis regarding its laboratory diagnosis and treatment.