沙眼衣原体疫苗研究的新进展

Update on the vaccine of Chlamydia trachomatis

沙眼衣原体感染是当今世界上最常见的性传播疾病，而疫苗一直是令人期待的预防和治疗沙眼衣原体感染的有效方法。20多年来临床医生及研究者做出了不懈的努力，近年来的研究主要集中于蛋白或多肽疫苗、树突状细胞疫苗和核酸疫苗上，其中尤以核酸疫苗引人注目。主要针对这三种疫苗，综述选用不同的载体、免疫佐剂及免疫途径等方法取得的成果及存在的缺陷，并探讨实施最佳免疫路径和发展新型疫苗的可能性等问题。

The infection of Chlamydia trachomatis is the most commonly sexually transmitted disease in the world, and vaccine has been expected to be an effective way to prevent and treat the infection. Many efforts have been offered to this field by clinicians and scientific researchers in the past twenty years. Recently, the studies are mainly concentrated on polypeptide vaccine, dendritic cell vaccine and DNA vaccine, and especially on DNA vaccine. This paper presents the progresses and problems in the researches about the vectors, immune adjuvants and immunization routes of the three kinds of vaccines. Also, the best immunization approach and possibility of new vaccine development are discussed.