妊娠梅毒与胎传梅毒

Maternal syphilis and congenital syphilis

近年来妊娠梅毒和胎传梅毒的发病率呈上升趋势。感染梅毒螺旋体后，由于免疫反应及细胞因子水平随病期的进展而变化，导致不同的妊娠结局，包括胚胎死亡、流产、早产或娩出胎传梅毒患儿；妊娠期间机体免疫反应状态的改变也会影响母体及胎传梅毒的自然病程。因此，进一步了解妊娠与梅毒的相互影响，揭示妊娠梅毒和胎传梅毒发生发展的规律，对于有效地控制梅毒的母婴传播，预防梅毒导致的不良妊娠结局，降低胎传梅毒的发病率具有重要意义。

Recently the incidence of syphilis in pregnant women and congenital syphilis has been increasing. Since the immune status and cytokine levels vary with the disease stage, untreated maternal syphilis could result in different outcomes, including stillbirth, abortion, premature delivery, and congenital syphilis. Moreover, the changes of immune status in pregnancy could influence the natural course of maternal syphilis and congenital syphilis. Thus, it is necessary to recognize the interaction between syphilis and gestation and to reveal the rules of occurrence and development of maternal syphilis and congenital syphilis for the effective control of mother-to-child transmission of Treponema pallidum, prevention of adverse pregnancy outcomes induced by syphilis and decrease of incidence of congenital syphilis.