解脲脲原体生物群致病性差异的进展

Difference in the pathogenicity between two biovars of Ureaplasma urealyticum

解脲脲原体在人群中的致病性一直是研究关注的重点。众多研究显示其致病性可能与特定的亚群和（或）基因型存在相关。根据表型和基因型特征，解脲脲原体两大生物群被建议区分为两个不同的微生物种群。近年来研究结果显示，解脲脲原体T960生物群与男性致病性的相关性更大，在临床工作中更应该被考虑到。解脲脲原体不同生物群在女性及新生儿中的致病性关系研究仍存在较多争议，但倾向于T960生物群可能与致病性关系更大，是致病菌群，而parvo生物群可能是定植菌群。

The pathogenicity of Ureaplasma urealyticum （Uu） in human has been a focus of studies. Numerous studies have disclosed that the pathogenicity may just relate to the specific biovars and/or serotypes of Uu. According to phenotypic and genotypic properties, the two biovars of Uu, T960 and parvo, are proposed to be classified into two disthet species. Recent studies have revealed that the pathogenicity of Uu in males mainly refers to the T960 biovar. Although there are still many arguments about the relationship between the two biovars of Uu and their pathogenicity in females and neonates, T960 tends to be considered as a pathogenic biovar, and parvo as a colonized one.