银屑病T细胞活化和信号转导的进展

T cell activation and signal transduction in psoriasis

银屑病发病与辅助性T细胞亚群分化失衡，活化T细胞信号转导失控及特定基因表达异常密切相关。T细胞可经抗原或非抗原刺激而活化，活化T细胞的信号转导途径有：Ca^2＋离子依赖的蛋白激酶C途径、Ras丝裂原活化的蛋白激酶途径和詹纳斯激酶一信号转导及转录活化因子途径等。其中詹纳斯激酶一信号转导及转录活化因子途径是细胞因子信号转导的主要途径。有效调控T细胞活化和信号转导途径对治疗银屑病有重要意义。

Numerous studies have shown that the pathogenesis of psoriasis is closely related to the differentiation unbalance of T helper cells, out of control of the signal transduction in activated T cells and abnormality of gene expression. T cells can be activated by antigenic or non-antigenic stimulation. There are three signal transduction pathways in activated T cells： Ca^2＋ dependent protein kinase C pathway, mitogen-activated protein kinases and Janus kinase signal transducer and activators of transcription （JAK-STAT） pathway, and JAK-STAT is the key pathway. So, it is important to effectively regulate T cell activation and signal transduction for psoriasis treatment.