摘要
目的:探讨单唾液酸四己糖神经节苷脂(GM1)对重度颅脑外伤的早期脑保护作用。方法:入选者随机分为GM1治疗组及生理盐水(NS)对照组;于治疗前和治疗7、14d各进行格拉斯哥昏迷评分(GCS),检测血清乳酸(La)及C-反应蛋白(CRP)作比较。结果:治疗7和14d后,治疗组La下降与对照组比较分别P<0.05和P<0.01;14d后治疗组GCS上升值与对照组比P<0.05。结论:GM1能够降低无氧代谢,减轻La堆积所致酸中毒,从而减轻脑水肿,起到保护脑组织改善预后的作用。
Aim: To study the protective effect of monosialoganglioside-GM1 on people inflicted of severe traumatic brain injury(STBI).Methods: People inflicted of STBI were devided into two groups randomly : GM1 -therapy group, NS-control group.To evaluate Glosgow Coma Score (GCS), jugular venous serum lactate and jugular venous serum response protein C acted on respectively pretherapy for 7 days and 14 days later. Results: The results showed that compared to NS group the jugular venous serum lactate declined significantly in GM1 group after 7 days and 14 days(P 〈 0.05, P 〈 0.01). GCS improved significantly in GM1 group compared with NS group 14 days later(P 〈 0.05). But the response protein C of GM1 group did not improve significantly compared to NS group after 7 days and 14 days(both P 〉 0.05). Conclusion: GM1 plays an important role in the recovery of the severe traumatic brain injury. It can improve cerebral oxygen supply,reduce anaerobic metabolism, relieve cerebral edema, act on brain protection effect.
出处
《中国临床神经科学》
2008年第1期57-60,共4页
Chinese Journal of Clinical Neurosciences