GBV-C／HIV共感染对AIDS疾病进程和HIV病毒复制的影响

Effect of GBV-C/HIV Coinfection on HIV/AIDS Disease Progression and HIV Replication

近年来,一些研究发现,GBV-C/HIV共感染可延缓HIV感染疾病的进程,然而也有一些研究得出不同的结论。本研究收集我国安徽省阜阳市HIV血清学阳性的既往献血员血浆标本,对其进行GBV-C感染的检测,研究GBV-C/HIV共感染与HIV病毒载量和CD4+T淋巴细胞绝对计数的关系。用RT-PCR和酶联免疫法检测,在203人中检出GBV-C感染52例,显示该人群GBV-C的感染率为25.6%,男性感染者(35例,67.3%)高于女性感染者(17例,32.7%)。分析发现,GBV-C感染与未感染两组患者的CD4+T淋巴细胞绝对计数和HIV病毒载量数据均无统计学差异。本研究中的HIV-1感染者均未接受ART治疗,因而排除了治疗对疾病进展的影响。研究结果显示,在HIV-1感染晚期的献血人群,GBV-C/HIV共感染对CD4细胞和病毒复制水平无显著影响。由于本研究对象中无HIV-1早期感染者,因而不能判断GBV-C在HIV-1感染的早期对疾病进展有无影响。

Several research groups have recently reported that persistent GB virus C （GBV-C） co-infected with human immunodeficiency virus （HIV） leads to slower AIDSs disease progression than HIV-1 infec- tion alone. However, these findings were not confirmed by several other studies. To investigate the association between GBV-C replication and plasma HIV loads and CD4＋ T cell counts, 203 HIV-1 positive for- mer blood/plasma donors（FBDs） were enrolled from Fuyang city of Anhui Province in China. Plasma spec- imens were collected from them and were tested for GBV-C using RT-PCR and ELISA. Out of 203 specimens, 52（25.6%） cases were positive for GBV-C, including 35 male （67.3%） and 17 female （32.7%） cases. No significant association was identified between GBV-C infection and CD4^＋ T-cell counts or between GBV-C infection and HIV viral loads. Since all the subjects studied were naive to ART, the influence of therapy on AIDS disease progression was ruled out in this study. Overall, our data indicated that HIV-1 positive male FBDs were prone to be infected, GBV-C coinfection with HIV-1 does not significantly influence HIV/AIDS disease progression during the late stage of chronic HIV-1 infection.