C57BL/6J-HBV转基因小鼠血清生化指标与性别年龄的关系

Relationship between the Blood Serum Index and Gender and Age in C57BL/6J-HBV Transgenic Mice

目的观察C57BL/6J-HBV乙型肝炎病毒转基因小鼠血清总胆红素(T-BIL)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总蛋白(TP)和白蛋白(ALB)与性别和年龄的关系,以及与遗传背景相同的C57BL/6J小鼠的差异。方法选取8周龄和24周龄的C57BL/6J-HBV转基因小鼠及C57BL/6J小鼠的血清测定T-BIL、ALT、AST、TP和ALB值。结果C57BL/6J-HBV转基因小鼠与同周龄同性别的C57BL/6J小鼠相比,T-BIL、ALT、AST、TP和ALB均存在显著差异(P<0.05);24周龄的C57BL/6J-HBV转基因小鼠ALT和AST与其8周龄鼠相比均存在显著差异(P<0.05)。结论C57BL/6J-HBV转基因小鼠T-BIL、ALT、AST、TP和ALB值显著高于C57BL/6J小鼠;且C57BL/6J-HBV转基因小鼠ALT和AST值与年龄有关,与性别无关。

Objective To observe relationship between some serum index, such as T-BIL, ALT, AST, TP, ALB, and gender as well as age in C57BL/6J-HBV transgenic mice.The differences between HBV mice and normal C57BL/6J mice in blood serum also determined. Methods Eight-week, twenty-four-week C57BL/6J-HBV transgenic mice and normal C57BL/6J were put into experiments, T-BIL, ALT, AST,TP and ALB of blood serum were determined. Results There was significant difference of T- BIL,ALT,AST, TP and ALB between HBV mice and C57BL/6J mice. The great differences of ALT and AST value were also observed in different age HBV mice. Conclusion The value of T-BIL,ALT,AST,TP and ALB is remarkable higher in HBV mice than that in C57BL/6J.The value of ALT and AST is related to the age of HBV mice and unrelated to the gender.