炎症性肠病动物模型的研究进展

Progress on Animal Model of Inflammatory Bowel Disease

克罗恩病和溃疡性结肠炎统称为炎症性肠病(IBD),病因虽不明确,但对其发病机理已有了较多的了解。该病的发生是由于个体易感性、肠道菌群和粘膜免疫相互作用所致。炎症性肠病动物模型可通过化学性诱导、免疫学、遗传学等方法获得。三硝基苯磺酸与乙醇灌肠致炎法是目前最常用的方法,本文侧重概述介绍三硝基苯磺酸诱导的炎症性肠病的机制、模型、应用及优缺点,为疾病的研究、治疗和新药的开发提供指导。

Crohn＇s disease and ulcerative colitis, collectively known as inflammatory bowel disease （IBD）, the etiology is not clear, but its pathogenesis has had more understanding. The incidence of the disease is due to individual susceptibility, and the intestinal flora induced mucosal immune interactions. Animal models of inflammatory bowel disease can be induced by chemical, immunology, genetics and other access methods. TNBS and ethanol enema proinflammatory France is the most commonly used method, this paper focuses on three outlined 2,4,6-trinitrobenzene sulfonic acid-induced inflammatory bowel disease mechanisms, models, applications and advantages and disadvantages the study of the disease, treatment and the development of new drugs to provide guidance.