宫颈上皮内瘤变电圈切除术对妊娠的影响

Pregnancy after Loop Electrical Excision Procedure of Cervical Intraepithelial Neoplasia.

目的探讨子宫颈上皮内瘤样病变（cervical intraepithelial neoplasia，CIN）行子宫颈电热圈环切术（loop electrical excision procedure。Leep）对妊娠是否会产生影响。方法临床已确诊的子宫颈上皮内瘤样病变Ⅱ-Ⅲ级者83例，行子宫颈电圈环切术者38例为观察组，未行子宫颈电圈环切术者45例为对照组，观察两组妊娠情况。结果与对照组相比，观察组早产发生率较高，有统计学差异。在受孕时间（6个月内、12个月内、24个月内、24个月后）、妊娠结局（自然流产、足月、不孕、异位妊娠、胎膜早破及低体重儿）、第1产程时间（潜伏期及活跃期）、术后并发症（宫颈粘连、宫颈狭窄及宫颈松弛）等方面统计学上无差异。结论合理的手术操作下，子宫颈上皮内瘤样病变行子宫颈电热圈环切术对妊娠是安全的。

Abstract Objective To investigate the effects of loop electrical excision procedure（LEEP） on pregnancy of patients with cervical epithelial neoplasia（ CIN）. Methods 83 patients with cervical intraepithelial neoplasia grade Ⅱ -Ⅲ have been diagnosed. Cervical loop trip were 38 cases for all of the observation group, did not undergo cervical loop were 45 cases for all the control group, observed pregnancy. Results There are significant differences in premature delivery between two groups （ P 〈 0.05 ）. No significant differences in pregnancy time （6 months, 12 months, 24 months, 24 months later） ,delivery outcomes（ spontaneous abortion,term, infertility,ectopic pregnancy, premature rupture of membrane and low birth weight infants） , the first stage of labor time （latent phase and active phase） ,Surgical complications （ cervical adhesion, Cervical stenosis and cervical stenosis relaxation） between two groups （ P 〉 0.05 ）. Conclusion Reasonable loop electrical excision procedure will not increase the risk of pregnancy.