癌胚抗原嵌合锚定T细胞对胃癌的体内外抑癌效应观察
被引量：3
摘要
增强免疫水平对提高胃癌疗效十分重要，我们利用共刺激信号CD3ζ对T细胞的活化作用和抗癌胚抗原（CEA）单链抗体的识别功能，构建真核表达载体。在此基础上制备CEA阳性嵌合锚定T细胞，观察其对CEA阳性胃癌裸鼠的抑癌效应，以期探讨嵌合锚定T细胞对消化道肿瘤的治疗作用。
出处
《中华外科杂志》
CAS
CSCD
北大核心
2008年第2期148-149,共2页
Chinese Journal of Surgery
基金
国家自然科学基金资助项目（39900068）志谢感谢张淼丽高级实验师在显微摄影中无私的帮助,感谢张波博士在统计学处理上给予的帮助
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