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乳腺癌组织中AQP1与HIF1表达的相关性 被引量：4

Correlation of aquaporin 1 with hypoxia-inducible factor 1 in breast cancer
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摘要 目的初步确定乳腺癌组织中水通道蛋白1（AQP1）与缺氧诱导因子1（HIF-1）是否存在相关性，以及相关特点。方法收集乳腺癌病例155例，应用免疫组织化学技术检测HIF-1阴性表达或阳性表达的乳腺癌组织中AQP1表达水平，初步确定二者之间是否存在相关性。结果HIF-1阴性表达或阳性表达的乳腺癌组织中AQP1表达水平（AQP1阳性细胞表达率分别为168±38、297±25），存在明显差异，二组结果比较差异有统计学意义（P〈0．001）。结论乳腺癌组织中AQ1l与HIF-1表达存在一定相关性，提示二者可能相互作用，共同调节乳腺癌的演进过程。 Objective To determinate the correlation of aquaporin 1 （AQP1） with hypoxia- inducible 1 （HIF 1 ）. Methods 155 samples of breast cancer obtained during radical mastectomy underwent immunohistochemistry to detect the expression of AQP1 and HIF1. Results The positive rate of AQP1 in the HIF1 positive group was 297 ± 25, significantly higher than that of HIF1 negative group （ 168 ± 38, P 〈0. 001 ）. Conclusion AQP1 is positively correlated with HIF1. The interaction of AQP1 and HIF1 may co-regulate the progress of breast cancer.
作者 殷铁军 于世英 肖亮 张珺 刘聪 卢运萍 刘承平
机构地区 华中科技大学同济医学院附属同济医院综合医疗科 华中科技大学同济医学院附属同济医院肿瘤科 华中科技大学同济医学院附属同济医院病理科 华中科技大学同济医学院附属同济医院妇产科 华中农业大学数学系
出处 《中华医学杂志》 CAS CSCD 北大核心 2008年第4期258-260,共3页 National Medical Journal of China
关键词 乳腺肿瘤 细胞低氧 水通道蛋白1 缺氧诱导因子1 Breast cancer Cell hypoxia Aquaporin 1 Hypoxia-inducible factor 1
分类号 R686 [医药卫生—骨科学]
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参考文献12

  • 1Gort EH, Groot AJ, Derks van de Ven TL, et al. Hypoxia-inducible factor-lalpha expression requires PI 3-Kinase activity and correlates with Aktl phosphorylation in invasive breast carcinomas. Oncogene, 2006,25:6123-6127.
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二级参考文献10

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中华医学杂志
2008年 第4期

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