呼吸道合胞病毒毛细支气管炎患儿尿白三烯测定及临床意义被引量：44

Clinical evaluation of urinary leukotriene E4 levels in infants with respiratory syncytial virus bronchiolitis

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摘要目的探讨呼吸道合胞病毒(RSV)毛细支气管炎(毛支)患儿尿白三烯E4(LTE4)的临床意义。方法采用竞争性酶联免疫吸附试验技术检测20例健康婴儿和30例RSV毛支患儿急性期和恢复期的尿LTE4水平;采用潮气分析测定急性期患儿呼吸频率(RR)、达峰时间比(tPTEF/tE)及达峰容积比(vPTEF/vE),分析其与尿LTE4水平的相关性。结果RSV毛支患儿急性期的尿LTE4比恢复期、正常健康组明显增高(P<0.01),恢复期与正常健康组相比差异无统计学意义(P>0.05);急性期毛支患儿潮气肺功能中RR增快、tPTEF/tE和vPTEF/vE下降,与正常健康组比较,差异有统计学意义(P<0.0001);急性期尿LTE4浓度与RR呈正相关(r=0.4376,P=0.0126),与tPTEF/tE和vPTEF/vE呈负相关(r=-0.6895,-0.6636,P均<0.001)。结论RSV毛支患儿尿LTE4增高,与肺功能指标呈负相关;尿LTE4浓度可作为RSV毛支临床诊治的非创伤性炎性指标。

作者项红霞赵德育

机构地区南京医科大学附属无锡市儿童医院南京医科大学附属南京市儿童医院

出处《临床儿科杂志》 CAS CSCD 北大核心 2008年第1期33-35,共3页 Journal of Clinical Pediatrics

关键词呼吸道合胞病毒毛细支气管炎尿白三烯E4 respiratory syncytial virus bronchiolitis urinary leukotriene E4

分类号 R725.6 [医药卫生—儿科]

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参考文献14

1Shay DK,Holman RC,Roosevelt GE,et al.Bronchiolitisassociated mortality and estimates of respiratory syncytial virus-associated deaths among US children,1979-1997[J].J Infect Dis,2001,183 (1):16-22.
2Sigurs N.Epidemiologic and clinical evidence of a respiratory syncytial virus-reactive airway disease link[J].Am J Respir Crit Care Med,2001,163(3pt 2):S2-S6.
3李兰,王智斌,李敏,陈昌辉,李波,吉德平,王运芳.毛细支气管炎血中半胱氨酰白三烯的测定及意义[J].四川大学学报（医学版）,2005,36(2):297-297. 被引量：27
4Dimova-Yaneva D,Russell D,Main M,et al.Eosinophil activation and cysteinyl leukotriene production in infants with respiratory syncytial virus bronchiolitis[J].Clin Exp Allergy,2004:34 (4):555-558.
5Oh JW,Shin SA,Lee HB.Urine leukotriene E and eosinoophil cationic protein in nasopharyngeal aspiration from young wheezy children[J].Pediatr Allergy Immunol,2005,16(5):416-421.
6Smith CM,Hawksworth RJ,Thien FC,et al.Urinary leukotriene E4 in bronchial asthma[J].Eur Respir J,1992,5(6):693-699.
7van Schaik SM,Tristram DA,Nagpal IS,et al.Increased production of IFN-gamma and cysteinyl leukotrienes in virusinduced wheezing[J].J Allergy Clin Immunol,1999,103(4):630-636.
8Wedde-Beer K,Hu C,Rodriguez MM,et al.Leukotrienes mediate neurogenic inflammation in lungs of young rats infected with respiratory syncytial virus[J].Am J Phy-siol Lung Cell Mol Physiol,2002,282 (5):1143-1150.
9Piedimonte G,Renzetti G,Auais A,et al.Leukotriene.synthesis during respiratory syncytial virus bronchiolitis:influence of age and atopy[J].Pediatr Pulmonol,2005,40(4):285-291.
10Bisgaard H.A randomized trial of montelukast in respiratory syncytial virus postbronchiolitis[J].The Study Group on Montelukast and Respiratory Syncytial Virus.Am J Respir Crit Care Med,2003,167 (3):379-383.

二级参考文献18

1[1]诸福棠,胡亚美,江载芳.实用儿科学.第7版.北京:人民卫生出版社,2002:1199～1200
2[5]Krilov LR, Mandel FS, Barone SR, et al. Follow-up of children with respiratory syncytial virus bronchiolitis in 1986 and 1987:potential effect of ribavirin on long term pulmonary function. Pediatr Infect Dis J,1997;16(3):276
3[6]Merth IT, De-Winter JP, Zonderland HM, et al.Pulmonary function during the first year of life following acute viral bronchiolitis. Am J Respir Crit Care Med, 1996;154(3): 69
4[7]Kattan M, Keens TG, Lapierre JG, et al. Pulmonary function abnormalities in symptom-free children after bronchiolitis. Pediatrics, 1977;59 : 683
5Pfaff JK,Morgan WJ. Pulmonary function in infants and children[J]. Pediatr Clin North Am, 1994, 41(2): 401-423.
6Hull CB. Respiratory syncytial virus and parainfluenza virus[J].N Engl J Med, 2001, 344(25): 1917-1928.
7胡亚美江载芳等主编.诸福棠实用儿科学(第7版)[M].北京:人民卫生出版社,2002.458～461.
8赵连云.肺功能领域新进展—强迫振荡技术[J].中国实用内科杂志,1997,17(10):625-626. 被引量：9
9符州,李成荣,杨锡强.毛细支气管炎细胞因子与发病机理的研究[J].免疫学杂志,1999,15(1):38-40. 被引量：55
10吴冀川,樊寻梅,刘玺成,王蕾.健康婴幼儿潮气流速容量曲线特点及意义[J].实用儿科临床杂志,1999,14(1):11-12. 被引量：37